S2 Genomics is Enabling Precision Medicine with Single Cell Spatial Sequencing and NGS Automation Technologies

Genomics and cell biology experiments performed at the single-cell level are advancing our understanding of biological complexity for both healthy and diseased tissue, revealing, for example, new cell subtypes in normal tissue and heterogeneity within solid tumors. These insights impact drug development and clinical applications of genomic information.

S2 Genomics develops laboratory automation solutions for processing solid tissues for single-cell applications. S2 Genomics’ technology platforms integrate advanced fluidics, optics, and biochemistry to produce automated sample preparation solutions for single-cell sequencing and cell biology markets, enabling discovery and innovation in life science research, healthcare, and agriculture. The Singulator™ 100 enables rapid and hands-off tissue dissociations, making it easy for researchers to reproducibly prepare suspensions of nuclei or highly viable cells from small samples in high yield, for a wide range of single-cell  analyses. The system includes single-use sample cartridges and proprietary reagents that allow researchers to isolate cells or nuclei rapidly, reproducibly, and with minimal impacts on the cellular transcriptome.

S2 is also developing single cell spatial sequencing technology that capture the spatial location, i.e., 3-dimensional coordinates, of single cells in tissue for NGS readout. Spatial sequencing™ is key to understanding tissue micro environments and how the diversity of heterogeneous cells affects human health, including cancer formation and progression; How the microbiome interacts with the host; Cell and tissue response to stimuli including therapeutic agents; and How organism and tissues develop, organize, function, and regenerate in all multi cellular organisms.

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